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LSD1-IN-34

CAT: 0804-HY-162729Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162729Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LSD1-IN-34 (Compound 7d) is the orally active inhibitor for Lysine-specific demethylase (LSD) and monoamine oxidase (MAO), with IC50 of 4.51 and 18.46 nM, for LSD1 and MAO A. LSD1-IN-34 inhibits the Ang II-induced neonatal rat myocardial fibroblasts (NRCFs) activation, without significant toxicity (20 μM) . LSD1-IN-34 inhibits TGFβ/Smad signaling pathway, and ameliorates heart failure in mice. LSD1-IN-34 exhibits good pharmacokinetic characteristics in rats[1].
CAS Number
3048029-74-6
UNSPSC
12352005
Target
Histone Demethylase; Monoamine Oxidase; TGF-beta/Smad
Type
Reference compound
Related Pathways
Epigenetics; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/lsd1-in-34.html
Smiles
FC1=CC([C@H]2[C@H](NCC3=CN(C4=CC=C(OCO5)C5=C4)N=N3)C2)=CC=C1F.Cl
Molecular Formula
C19H17ClF2N4O2
Molecular Weight
406.81
References & Citations
[1]Huang MJ, et al., Design, Synthesis, and Evaluation of the Selective and Orally Active LSD1 Inhibitor with the Potential of Treating Heart Failure. J Med Chem. 2024 Aug 8;67 (15) :13409-13434.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1; MAO-A; MAO-B

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