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SB-272183

CAT: 0804-HY-116908Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116908Size:1 Each
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Description
SB-272183 is a selective 5-HT1A, 5-HT1B and 5-HT1D receptor antagonist. In addition, SB-272183 is also a potent and selective ligand for 5-HT1A, 5-HT1B and 5-HT1D receptors in human recombinant and native tissues with pKi values of 8.0, 8.1 and 8.7, respectively. SB-272183 can be used in antidepressant research[1].
CAS Number
216058-27-4
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-272183.html
Smiles
O=C(N1C2=CC(N3CCN(CC3)C)=C(C=C2CC1)Cl)NC4=C5C=CC=CC5=C(C6=CC=NC=C6)C=C4
Molecular Formula
C29H28ClN5O
Molecular Weight
498.02
References & Citations
[1]Watson J, et al. SB‐272183, a selective 5‐HT1A, 5‐HT1B and 5‐HT1D receptor antagonist in native tissue[J]. British journal of pharmacology, 2001, 133 (6) : 797-806.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3

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