AChE/Aβ-IN-6

• UNSPSC Description:

  BACE1-IN-15 (compound 4j) is a potent inhibitor of BACE1 (β-secretase) that can inhibited the copper ion induced Aβ toxicity, with the EC50 of 0.68 μM[1].

• Target Antigen:

  Amyloid-β; Beta-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ache-aβ-in-6.html

• Smiles:

  O=C(NCC1=CN(CC2=CC=C(C(F)(F)F)C=C2)N=N1)/C=C/C3=CC=CC=C3

• Molecular Weight:

  386.37

• References & Citations:

  [1]Lin-Jie Tan, et al. Discovery of cinnamamide/ester triazole hybrids as potential treatment for Alzheimer’s disease. Bioorganic Chemistry Volume 150, September 2024, 107584.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported