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AChE-IN-6

CAT: 0804-HY-144324Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144324Size:1 Each
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Description
AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils) . AChE-IN-6 has the potential for the research of Alzheimer's disease[1].
CAS Number
2758788-95-1
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-6.html
Solubility
10 mM in DMSO
Smiles
CCN(CC1=C(C=CC=C1)N(C)C)CCCCCCN2N=C(C=CC2=O)C3=CC(N(C)C)=CC=C3O
Molecular Formula
C29H41N5O2
Molecular Weight
491.67
References & Citations
[1]Shi Y, et al. Development of novel 2-aminoalkyl-6- (2-hydroxyphenyl) pyridazin-3 (2H) -one derivatives as balanced multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2022;230:114098.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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