AChE-IN-6

• Description:

  AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils) . AChE-IN-6 has the potential for the research of Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ache-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCN (CC1=C (C=CC=C1) N (C) C) CCCCCCN2N=C (C=CC2=O) C3=CC (N (C) C) =CC=C3O

• Molecular Formula:

  C29H41N5O2

• Molecular Weight:

  491.67

• References & Citations:

  [1]Shi Y, et al. Development of novel 2-aminoalkyl-6- (2-hydroxyphenyl) pyridazin-3 (2H) -one derivatives as balanced multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2022;230:114098.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE

• CAS Number:

  2758788-95-1