AChE-IN-6

• Description :

  AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils) . AChE-IN-6 has the potential for the research of Alzheimer's disease[1].

• UNSPSC :

  12352005

• Target :

  Cholinesterase (ChE)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ache-in-6.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCN(CC1=C(C=CC=C1)N(C)C)CCCCCCN2N=C(C=CC2=O)C3=CC(N(C)C)=CC=C3O

• Molecular Formula :

  C29H41N5O2

• Molecular Weight :

  491.67

• References & Citations :

  [1]Shi Y, et al. Development of novel 2-aminoalkyl-6- (2-hydroxyphenyl) pyridazin-3 (2H) -one derivatives as balanced multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2022;230:114098.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE

• CAS Number :

  [2758788-95-1]