Galectin-3-IN-3

Galectin-3-IN-3

• CAS Number: 2491661-50-6
• UNSPSC Description: Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC50 values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively[1].
• Target Antigen: Galectin
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/galectin-3-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: CO[C@H]1[C@@H](O[C@@H]([C@@H]([C@@H]1N2C=C(N=N2)C3=C(C(F)=C(C=C3)Cl)F)O)CO)C4=NC(C)=NN4C5=CC6=C(N=CS6)C=C5
• Molecular Weight: 590.00
• References & Citations: [1]Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024;101:117638.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported