Galectin-3-IN-3

• UNSPSC Description:

  Galectin-3-IN-3 (Compound 4) is an orally active and selective inhibitor of Gal-3, with IC50 values of 11 nM and 84 nM against mGal-3 and hGal-3 respectively[1].

• Target Antigen:

  Galectin

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/galectin-3-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CO[C@H]1[C@@H](O[C@@H]([C@@H]([C@@H]1N2C=C(N=N2)C3=C(C(F)=C(C=C3)Cl)F)O)CO)C4=NC(C)=NN4C5=CC6=C(N=CS6)C=C5

• Molecular Weight:

  590.00

• References & Citations:

  [1]Liu C, et al. Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design. Bioorg Med Chem. 2024;101:117638.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2491661-50-6