Galectin-3/galectin-8-IN-2

• UNSPSC Description:

  Galectin-3/galectin-8-IN-2 (Compound 57) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 12.8 μM and 2.06 μM respectively. Galectin-3/galectin-8-IN-2 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-2 can be used for research of cancer and tissue fibrosis[1].

• Target Antigen:

  Galectin

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/galectin-3-galectin-8-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(N1)=CC2=C1C=CC(OC3=CC=C(Cl)C(Cl)=C3)=C2)NS(=O)(C4=C(CC5=CC=CC=C5)C=CS4)=O

• Molecular Weight:

  557.47

• References & Citations:

  [1]Haoming Zhang, et al. Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Galectin-3 and Galectin-8 C-Terminal Domain Inhibitors. ACS Med. Chem. Lett. 2023, 14, 9, 1257-1265.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported