Galectin-3/galectin-8-IN-2

Galectin-3/galectin-8-IN-2

• UNSPSC Description: Galectin-3/galectin-8-IN-2 (Compound 57) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 12.8 μM and 2.06 μM respectively. Galectin-3/galectin-8-IN-2 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-2 can be used for research of cancer and tissue fibrosis[1].
• Target Antigen: Galectin
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/galectin-3-galectin-8-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C(N1)=CC2=C1C=CC(OC3=CC=C(Cl)C(Cl)=C3)=C2)NS(=O)(C4=C(CC5=CC=CC=C5)C=CS4)=O
• Molecular Weight: 557.47
• References & Citations: [1]Haoming Zhang, et al. Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Galectin-3 and Galectin-8 C-Terminal Domain Inhibitors. ACS Med. Chem. Lett. 2023, 14, 9, 1257-1265.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported