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Galectin-3/galectin-8-IN-2

CAT: 0804-HY-155192Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155192Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Galectin-3/galectin-8-IN-2 (Compound 57) is a dual Galectin-3 and galectin-8 C-terminal domain inhibitor, with Kd values of 12.8 μM and 2.06 μM respectively. Galectin-3/galectin-8-IN-2 inhibits the MRC-5 lung fibroblast cells migration. Galectin-3/galectin-8-IN-2 can be used for research of cancer and tissue fibrosis[1].
UNSPSC
12352005
Target
Galectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/galectin-3-galectin-8-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N1)=CC2=C1C=CC(OC3=CC=C(Cl)C(Cl)=C3)=C2)NS(=O)(C4=C(CC5=CC=CC=C5)C=CS4)=O
Molecular Formula
C26H18Cl2N2O4S2
Molecular Weight
557.47
References & Citations
[1]Haoming Zhang, et al. Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Galectin-3 and Galectin-8 C-Terminal Domain Inhibitors. ACS Med. Chem. Lett. 2023, 14, 9, 1257-1265.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Galectin-3; Galectin-8

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