CCX-777

• Description:

  CCX-777 is a partial agonist of β-arrestin-2 recruitment to ACKR3 (atypical chemokine receptor 3) [1].

• UNSPSC:

  12352005

• Target:

  Arrestin

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ccx-777.html

• Concentration:

  10mM

• Purity:

  98.73

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(NCCN1CCCC1)CC(N2CCN(C3=C4N=CC=CC4=CC=C3OC)CCC2)C5=CSC(N6CCOCC6)=N5

• Molecular Formula:

  C31H43N7O3S

• Molecular Weight:

  593.78

• References & Citations:

  [1]Gustavsson M, et al. Structural basis of ligand interaction with atypical chemokine receptor 3. Nat Commun. 2017 Jan 18;8:14135.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1226686-36-7]