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APT STAT3

CAT: 0804-HY-P10115-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P10115-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APT STAT3 is a specific STAT3-binding peptide. APT STAT3 can bind STAT3 with high specificity and affinity (～231 nmol/L) . APT STAT3 is a tractable agent for translation to target the broad array of cancers harboring constitutively activated STAT3[1].
CAS Number
[1345420-96-3]
UNSPSC
12352209
Target
STAT
Type
Peptides
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apt-stat3.html
Purity
99.38
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C([C@@H](C(=O)N1[C@H](C(NCC(N[C@H](C(N[C@@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC=6C=7C(NC6)=CC=CC7)C(N[C@H](C(N[C@@H](CC=8C=9C(NC8)=CC=CC9)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC%10=CC=C(O)C=C%10)C(N[C@H](C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CC(C)C)=O)=O)CCC(N)=O)=O)=O)C)=O)=O)CCCCN)=O)=O)[C@@H](C)O)=O)=O)CCCCN)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)=O)CO)=O)=O)CCC1)NC([C@@H](NC([C@H](CC%12=CC=CC=C%12)NC(CNC([C@H](CC%13=CN=CN%13)N)=O)=O)=O)CCC(N)=O)=O)C=%14C=%15C(NC%14)=CC=CC%15
Molecular Formula
C158H205N39O36
Molecular Weight
3226.56
References & Citations
[1]Kim D, et al. A specific STAT3-binding peptide exerts antiproliferative effects and antitumor activity by inhibiting STAT3 phosphorylation and signaling. Cancer Res. 2014 Apr 15;74 (8) :2144-51.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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