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PROTAC K-Ras Degrader-3

CAT: 0013-GTR19238854-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19238854-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC K-Ras Degrader-3 (compound 40) is a potent, cell-permeable degrader of K-Ras G12D, demonstrating a DC50 ≤ 1 nM in SW620 cells and a GI50 ≤ 10 nM in 3D proliferation assays. This tool compound is valuable for investigating targeted protein degradation as a therapeutic strategy in oncology research, both in vitro and in vivo.
CAS Number
3043670-68-1
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Smiles
C (N1CC2 (C1) CCN (CC2) C=3C=C4C (=CC3) C (=O) N (C4) [C@@H]5C (=O) NC (=O) CC5) C6 (C) CCN (CC7 (COC=8N=C (C9=C (N8) C (F) =C (N=C9) C=%10C%11=C (C=C (O) C%10) C=CC (F) =C%11CC) N%12C[C@] (C) (O) CCC%12) CC7) CC6
Molecular Formula
C57H67F2N9O6
Molecular Weight
1012.20
Storage Conditions
-20°C
Notes
For research use only.

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