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PROTAC K-Ras Degrader-2

CAT: 0931-T204910-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204910-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3043670-74-9
Target
PROTACs, Ras, Kras
Related Pathways
GPCR/G Protein, MAPK, PROTAC
Bioactivity
PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V/RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.
Smiles
C(C1(COC=2N=C(C3=C(N2)C(F)=C(N=C3)C=4C5=C(C=C(O)C4)C=CC(F)=C5CC)N6C[C@](C)(O)CCC6)CC1)N7CCC(CN8CCN(CC8)C9=CC(F)=C(C(F)=C9)C%10C(=O)NC(=O)CC%10)(C)CC7
Molecular Formula
C52H60F4N8O5
Molecular Weight
953.077
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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