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EGFR-IN-129

CAT: 0804-HY-163000Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163000Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-129 (Compound 10b) is a potent and selective EGFR inhibitor, with an IC50 of 51.2 nM. EGFR-IN-129 exhibits broadest-spectrum antiproliferative activity against the NCI-tumor panel[1].
UNSPSC
12352211
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-129.html
Smiles
COC1=CC(C2=NC(NC3=CC=C(S(=O)(N)=O)C=C3)=C(C=CC=C4)C4=N2)=CC=C1
Molecular Formula
C21H18N4O3S
Molecular Weight
406.46
References & Citations
[1]Eldehna WM, et al. Discovery of new sulfonamide-tethered 2-aryl-4-anilinoquinazolines as the first-in-class dual carbonic anhydrase and EGFR inhibitors. Int J Biol Macromol. 2024 Nov;279 (Pt 2) :135010.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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