PROTAC SMARCA2/4-degrader-29

• CAS Number:

  2568273-82-3

• UNSPSC Description:

  PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades SMARCA2 in A549 with DC50 SMARCA4 in MV411 with DC50 [1].

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-4-degrader-29.html

• Smiles:

  O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C([C@@H]4CC[C@H](N5CCC(C6=NC=CC(N7C8CN(C9=C(N)N=NC(C%10=C(C=CC=C%10)O)=C9)CC7CC8)=N6)CC5)CC4)C=C3N1C

• Molecular Weight:

  797.95

• References & Citations:

  [1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported