PROTAC SMARCA2/4-degrader-29

PROTAC SMARCA2/4-degrader-29

• CAS Number: 2568273-82-3
• UNSPSC Description: PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades SMARCA2 in A549 with DC50 SMARCA4 in MV411 with DC50 [1].
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-4-degrader-29.html
• Smiles: O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C([C@@H]4CC[C@H](N5CCC(C6=NC=CC(N7C8CN(C9=C(N)N=NC(C%10=C(C=CC=C%10)O)=C9)CC7CC8)=N6)CC5)CC4)C=C3N1C
• Molecular Weight: 797.95
• References & Citations: [1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported