PROTAC SMARCA2/4-degrader-27

PROTAC SMARCA2/4-degrader-27

• CAS Number: 2375564-54-6
• UNSPSC Description: PROTAC SMARCA2/4-degrader-27 (PROTAC 2) is a PROTAC-based degrader of SMARCA2 and SMARCA4. (Blue: CRL2VHL ligand VH032-cyclopropane-F (HY-125905); Black: linker (HY-159678);Pink: a SMARCA-BD ligand 1 for PROTAC (HY-44012))[1].
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-4-degrader-27.html
• Smiles: O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=C(C=C(C4=C(C)N=CS4)C=C3)OCCC5=CC=C(C=C5)CN6CCN(C7=C(N)N=NC(C8=C(C=CC=C8)O)=C7)CC6)=O)=O
• Molecular Weight: 920.10
• References & Citations: [1]Angus D. Cowan, et al. Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory. Annu. Rev. Biochem. 2022. 91:295-319.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported