PROTAC SMARCA2/4-degrader-4

PROTAC SMARCA2/4-degrader-4

• CAS Number: 2568523-81-7
• UNSPSC Description: PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC50 SMARCA4 in MV411 with DC50 [1]
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-4-degrader-4.html
• Smiles: O=C([C@H]1N(C[C@H](O)C1)C([C@@H](NC([C@H](C2)C[C@@]32C[C@H](C4=CC=C(CN5CCC(CC5)CN6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)C=C4)C3)=O)C(C)(C)C)=O)NCC9=CC=C(C%10=C(C)N=CS%10)C=C9
• Molecular Weight: 991.25
• References & Citations: [1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported