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NZ-66

CAT: 0804-HY-158408Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158408Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NZ-66 is a UNC-51-like kinase 1 (ULK1) targeting chimera, which is used to achieve proximity-induced and ULK1-dependent degradation of mitochondria. NZ-66 induces mitophagy. NZ-66 is potential for attenuating neurodegenerative disorders[1].
CAS Number
3062992-25-7
UNSPSC
12352005
Target
Mitophagy; ULK
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nz-66.html
Smiles
O=C(NC1=CC=C(F)C=C1F)[C@H](NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)C3=CC=C(OCC4=CN(CCCCCCNC(C(C5=C(C6=CC=CC=C6)NC7=C5C=CC=C7)=O)=O)N=N4)C=C3
Molecular Formula
C48H40F8N8O5
Molecular Weight
960.87
References & Citations
[1]Zaman N, et al. Development of the ULK1-Recruiting Chimeras (ULKRECs) to enable proximity-induced and ULK1-dependent degradation of mitochondria[J]. bioRxiv, 2024: 2024.04. 15.589474.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ULK1

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