NZ-66

• Target :

  Mitophagy|||Autophagy

• Related Pathways :

  Autophagy

• Bioactivity :

  NZ-66 is a chimeric molecule that targets UNC-51-like kinase 1 (ULK1) to facilitate proximity-induced, ULK1-dependent mitochondrial degradation. It triggers mitophagy (mitochondrial autophagy) and has potential for alleviating neurodegenerative diseases.

• Smiles :

  C(C(NCCCCCCN1C=C(COC2=CC=C([C@H](C(NC3=C(F)C=C(F)C=C3)=O)NC(NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=O)C=C2)N=N1)=O)(=O)C5=C(NC=6C5=CC=CC6)C7=CC=CC=C7

• Molecular Formula :

  C48H40F8N8O5

• Molecular Weight :

  960.87

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3062992-25-7