NZ-28

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  NZ28, also known as NSC134754, is potent HSF1 inhibitor, which induced inhibition of HSF1, SP1 and NF-?B triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.

• Smiles:

  C(C=1C[C@]2(C=3C(=CC(OC)=C(OC)C3)CCN2CC1CC)[H])[C@@H]4C=5C(CCN4)=CC=CC5

• Molecular Formula:

  C27H34N2O2

• Molecular Weight:

  418.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  75041-32-6