NZ-804

• Description:

  NZ-804 is an orally active inhibitor for SARS-CoV-2 main protease Mpro with an IC50 of 8.9 nM. NZ-804 inhibits the SARS-CoV-2 replication in HeLa-hACE2 cell with an EC50 of 14 nM. NZ-804 exhibits board-spectrum antiviral activity aganst multiple CoVs. NZ-804 diminishes virus replication in mouse and hamster model[1].

• UNSPSC:

  12352005

• Target:

  SARS-CoV; Virus Protease

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C(N1CC/C(CC1)=C2C3=C(CS(=O)(C4=C/2C=CC=C4)=O)C=CC=C3)C5=CN=CC6=C5NC=C6

• Molecular Formula:

  C27H23N3O3S

• Molecular Weight:

  469.55

• References & Citations:

  [1]Zhou NE, et al., An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo. Cell Rep. 2024 Nov 26;43 (11) :114929.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2858658-44-1]