MMP-11 Recombinant Rabbit Monoclonal Antibody [SN74-08]

MMP-11 Recombinant Rabbit Monoclonal Antibody [SN74-08]

• Description: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including Collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also called stromelysin-1, -2 and -3) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
• Product Name Alternative: Matrix Metalloproteinase 11 antibody Matrix metalloproteinase-11 antibody MMP-11 antibody Mmp11 antibody MMP11_HUMAN antibody SL 3 antibody SL-3 antibody SL3 antibody ST3 antibody STMY3 antibody Stromelysin 3 antibody Stromelysin III antibody Stromelysin-3 antibody
• Abbreviation: SL-3, ST3, MMP-11, MMP11
• CAS Number: 9000-83-3
• Swiss Prot: P24347 Human, Q02853 Mouse, Q499S5 Rat
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human MMP11 aa 439-488 / 488.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P
• Positive Control: 293T cell lysate, MCF7 cell lysate, mouse kidney tissue lysate, mouse lung tissue lysate, mouse testis tissue lysate, rat testis tissue lysate, SW480, MCF-7, A549, human spleen tissue, human breast carcinoma tissue, mouse spleen tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IF-Cell: 1:500-1:1,000 ;IF-Tissue: 1:500-1:1,000 ;IHC-P: 1:100-1:5000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 55 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes