MMP-3 Rabbit Polyclonal Antibody

Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP-3 has an estimated molecular weight of 54 kDa. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix proteins and during tissue remodeling in normal physiological processes, such as embryonic development and reproduction, as well as in disease processes, such as arthritis, and tumour metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. In addition to classical roles for MMP3 in extracellular space, MMP3 can enter in cellular nuclei and control transcription.

9007-83-4

CHDS6 antibody Matrix metalloproteinase 3 antibody Matrix metalloproteinase-3 antibody MGC126102 antibody MGC126103 antibody MGC126104 antibody MMP 3 antibody MMP-3 antibody MMP3 antibody MMP3_HUMAN antibody Proteoglycanase antibody SL-1 antibody SL1 antibody STMY antibody STMY1 antibody STR1 antibody Stromelysin 1 antibody Stromelysin-1 antibody Transin 1 antibody Transin-1 antibody

SL-1, MMP-3, MMP3, STMY1

P08254 Human, P28862 Mouse, P03957 Rat

Extracellular matrix. Secreted.

Recombinant protein within C-terminal human MMP-3.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell, IHC-P, FC

U-87 MG cell lysate, HeLa cell lysate, A549, LOVO, human liver tissue, mouse liver tissue, rat liver tissue, rat brain tissue, human tonsil tissue, human colon cancer tissue, mouse brain tissue.

1 mg/mL

WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:1,000 ;FC: 1:50-1:100

Immunogen affinity purified.

Liquid

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 54 kDa

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.