MMP-7 Rabbit Polyclonal Antibody
CAT:
992-HA500305
Size:
100 µL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MMP-7 Rabbit Polyclonal Antibody
- Description: MMP7 was initially characterized by Woessner et al. It digests components of the extracellular matrix, cleaves the α 2 (I) chain of gelatin more rapidly, and digests the B chain of insulin at Ala14-Leu and Tyr16-Leu, and has no action on collagen types I, II, IV, V. The optimal pH of MMP7 is at 7 and the pI is at 5.9. MMP4 is inhibited by α 2-macroglobulin and TIMP. The inhibition of MMP7 activity commonly relies on metal-chelating agents including EDTA and 1,10-phenantroline, especially zinc chelation. Therefore, the selectivity of MMP7 inhibition is challenging since almost all members of MMPs family contain catalytic domains with zinc binding sites. TIMP-1 and 2 noncovalently bound to active MMP7 at the catalytic site inhibiting MMP7 activity. The activated MMP7 can also cleave the propeptides of proMMP2 and proMMP9 to facilitate tumor invasion.
- Product Name Alternative: Matrilysin antibody Matrin antibody Matrix Metalloproteinase 7 antibody Matrix metalloproteinase-7 antibody MMP 7 antibody MMP-7 antibody MMP7 antibody MMP7_HUMAN antibody MPSL1 antibody PUMP 1 antibody Pump 1 protease antibody Pump-1 protease antibody PUMP1 antibody Uterine matrilysin antibody Uterine metalloproteinase antibody
- Abbreviation: Matrilysin Matrin Matrix metalloproteinase-7 MMP-7 Pump-1 protease Uterine metalloproteinase
- CAS Number: 9007-83-4
- Swiss Prot: P09237 Human
- Cellular Locus: Extracellular matrix, Secreted.
- Host: Rabbit
- Species Reactivity: Human
- Immunogen: Synthetic peptide within human MMP7 aa 220-267 / 267.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IF-Cell, IHC-P, FC
- Positive Control: A549 cell lysates, HT-29 cell lysate, A431 cell lysate, A549, human uterus tissue, HT-29.
- Concentration: 1 mg/mL
- Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:100 ;FC: 1:500-1:1.000
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: 42 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
- Recombinant Antibody: No