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MMP-7 Rabbit Polyclonal Antibody

CAT: 0992-HA500305Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500305Size:100 µL
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Description
MMP7 was initially characterized by Woessner et al. It digests components of the extracellular matrix, cleaves the α 2 (I) chain of gelatin more rapidly, and digests the B chain of insulin at Ala14-Leu and Tyr16-Leu, and has no action on collagen types I, II, IV, V. The optimal pH of MMP7 is at 7 and the pI is at 5.9. MMP4 is inhibited by α 2-macroglobulin and TIMP. The inhibition of MMP7 activity commonly relies on metal-chelating agents including EDTA and 1,10-phenantroline, especially zinc chelation. Therefore, the selectivity of MMP7 inhibition is challenging since almost all members of MMPs family contain catalytic domains with zinc binding sites. TIMP-1 and 2 noncovalently bound to active MMP7 at the catalytic site inhibiting MMP7 activity. The activated MMP7 can also cleave the propeptides of proMMP2 and proMMP9 to facilitate tumor invasion.
CAS Number
9007-83-4
Product Name Alternative
Matrilysin antibody Matrin antibody Matrix Metalloproteinase 7 antibody Matrix metalloproteinase-7 antibody MMP 7 antibody MMP-7 antibody MMP7 antibody MMP7_HUMAN antibody MPSL1 antibody PUMP 1 antibody Pump 1 protease antibody Pump-1 protease antibody PUMP1 antibody Uterine matrilysin antibody Uterine metalloproteinase antibody
Abbreviation
Matrilysin Matrin Matrix metalloproteinase-7 MMP-7 Pump-1 protease Uterine metalloproteinase
Swiss Prot
P09237 Human
Cellular Locus
Extracellular matrix, Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human MMP7 aa 220-267 / 267.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
A549 cell lysates, HT-29 cell lysate, A431 cell lysate, A549, human uterus tissue, HT-29.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:100 ;FC: 1:500-1:1.000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
42 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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