MMP-14 Recombinant Rabbit Monoclonal Antibody [SJ18-09]

MMP-14 Recombinant Rabbit Monoclonal Antibody [SJ18-09]

• Description: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. Membrane-type matrix metalloproteinases, including MT-MMP-1 (also designated MMP-14), MT-MMP-2 (also designated MMP-15), MT-MMP-3 (also designated MMP-16) and MT-MMP-4 (also designated MMP-17) are type I membrane proteins that function to activate other MMPs. MT-MMP activation appears to be mediated by members of the proprotein convertase family, suggesting that a proprotein convertase/MT-MMP/MMP cascade may be involved in the regulation of ECM turnover.
• Product Name Alternative: Matrix metallopeptidase 14 (membrane inserted) antibody Matrix metalloproteinase 14 antibody Matrix metalloproteinase-14 antibody Membrane type 1 matrix metalloproteinase antibody Membrane type 1 metalloprotease antibody Membrane type matrix metalloproteinase 1 antibody Membrane-type matrix metalloproteinase 1 antibody Membrane-type-1 matrix metalloproteinase antibody MMP 14 antibody MMP X1 antibody MMP-14 antibody MMP-X1 antibody Mmp14 antibody MMP14_HUMAN antibody MMPX1 antibody MT MMP 1 antibody MT-MMP 1 antibody MT1 MMP antibody MT1-MMP antibody MT1MMP antibody MTMMP 1 antibody MTMMP1 antibody
• Abbreviation: MMP-14, MTMMP1, MT1-MMP, MT1MMP, MT-MMP 1
• CAS Number: 9000-83-3
• Swiss Prot: P50281 Human, P53690 Mouse, Q10739 Rat
• Cellular Locus: Membrane, Melanosome, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human MMP14 aa 149-200 / 582.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
• Positive Control: Human kidney tissue lysates, CRC, BT-20, human breast carcinoma tissue, human kidney tissue, human uterus tissue, A549.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:2000 ;IHC-P: 1:50-1:10,000 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 66 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes