Phospho-SHP2 (Y542) Recombinant Rabbit Monoclonal Antibody [SN61-01]

Phospho-SHP2 (Y542) Recombinant Rabbit Monoclonal Antibody [SN61-01]

• Description: Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
• Product Name Alternative: BPTP3 antibody CFC antibody JMML antibody METCDS antibody MGC14433 antibody NS1 antibody OTTHUMP00000166107 antibody OTTHUMP00000166108 antibody Protein tyrosine phosphatase 2 antibody Protein tyrosine phosphatase 2C antibody Protein tyrosine phosphatase non receptor type 11 antibody Protein-tyrosine phosphatase 1D antibody Protein-tyrosine phosphatase 2C antibody PTN11_HUMAN antibody PTP-1D antibody PTP-2C antibody PTP1D antibody PTP2C antibody PTPN11 antibody SAP2 antibody SH-PTP2 antibody SH-PTP3 antibody SH2 domain containing protein tyrosine phosphatase 2 antibody SHP 2 antibody SHP-2 antibody Shp2 antibody SHPTP2 antibody SHPTP3 antibody Syp antibody Tyrosine-protein phosphatase non-receptor type 11 antibody
• Abbreviation: PTP-1D, PTP-2C, SHP-2, Shp2, PTPN11
• CAS Number: 9000-83-3
• Swiss Prot: Q06124 Human, P35235 Mouse
• Cellular Locus: Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Mouse, Human
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Tyr542 of Human SHP2 aa 511-560 / 593.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IP
• Positive Control: NIH/3T3 treated with 40ng/ml PDGF for 40 minutes whole cell lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 68 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes