Phospho-eIF4E (S209) Recombinant Rabbit Monoclonal Antibody [SU0396]

Phospho-eIF4E (S209) Recombinant Rabbit Monoclonal Antibody [SU0396]

• Description: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm.Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap.Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis.In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation.May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development.
• Product Name Alternative: AUTS19 antibody CBP antibody eIF 4E antibody eIF 4F 25 kDa subunit antibody EIF 4F antibody eIF-4E antibody eIF-4F 25 kDa subunit antibody eIF4E antibody EIF4E1 antibody EIF4EL1 antibody EIF4F antibody Eukaryotic translation initiation factor 4 E antibody Eukaryotic translation initiation factor 4E antibody Eukaryotic translation initiation factor 4E like 1 antibody IF4E_HUMAN antibody Messanger RNA Cap Binding Protein eIF 4E antibody MGC111573 antibody mRNA cap binding protein antibody mRNA cap-binding protein antibody
• Abbreviation: eIF-4E, eIF4E, EIF4E
• CAS Number: 9000-83-3
• Swiss Prot: P06730 Human, P63073 Mouse, P63074 Rat
• Cellular Locus: Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser209 of human eIF4E.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, IP
• Positive Control: Mouse spleen tissue lysate, rat spleen tissue lysate, NIH3T3 cell lysate, N2A, SH-SY5Y, 293, human pancreas tissue, rat spleen tissue, mouse brain tissue, mouse hippocampus tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 25 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes