Phospho-TrkB (Y817) Recombinant Rabbit Monoclonal Antibody [SC0556]

Phospho-TrkB (Y817) Recombinant Rabbit Monoclonal Antibody [SC0556]

• Description: The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by NTRK2, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B and is a functional receptor for NT-3.
• Product Name Alternative: AI848316 antibody BDNF tropomyosine receptor kinase B antibody BDNF/NT 3 growth factors receptor antibody BDNF/NT-3 growth factors receptor antibody Brain derived neurotrophic factor receptor antibody C030027L06Rik antibody EC 2.7.10.1 antibody GP145 TrkB antibody GP145-TrkB antibody GP145-TrkB/GP95-TrkB antibody GP95 TrkB antibody Neurotrophic receptor tyrosine kinase 2 antibody Neurotrophic tyrosine kinase receptor type 2 antibody Neurotrophin receptor tyrosine kinase type 2 antibody NTRK 2 antibody Ntrk2 antibody NTRK2_HUMAN antibody Obesity, hyperphagia, and developmental delay, included antibody RATTRKB1 antibody Tkrb antibody Trk B antibody Trk-B antibody TRKB antibody TrkB tyrosine kinase antibody TRKB1 antibody Tropomyosin related kinase B antibody tyrosine kinase receptor B antibody Tyrosine receptor kinase B antibody
• Abbreviation: Trk-B, NTRK2
• CAS Number: 9000-83-3
• Swiss Prot: Q16620 Human, P15209 Mouse, Q63604 Rat
• Cellular Locus: Cell membrane, Endosome membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Tyr817 of Human TrkB aa 789-822 / 822.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP
• Positive Control: Mouse brain tissue lysate, rat brain tissue lysate, PANC-1, SH-SY5Y, human brain tissue, mouse brain tissue, rat brain tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:200 ;IHC-P: 1:1,000 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 92 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes