Phospho-GluR1 (S845) Recombinant Rabbit Monoclonal Antibody [JJ2009]

Phospho-GluR1 (S845) Recombinant Rabbit Monoclonal Antibody [JJ2009]

• Description: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.
• Product Name Alternative: GLUR 1 antibody GLUR A antibody AMPA 1 antibody AMPA selective glutamate receptor 1 antibody AMPA-selective glutamate receptor 1 antibody GluA1 antibody GLUH1 antibody GluR K1 antibody GluR-1 antibody GluR-A antibody GluR-K1 antibody GLUR1 antibody GLURA antibody GluRK1 antibody Glutamate receptor 1 antibody Glutamate receptor ionotropic AMPA 1 antibody Glutamate receptor ionotropic antibody Glutamate receptor, ionotropic, AMPA 1 antibody Gria1 antibody GRIA1_HUMAN antibody HBGR1 antibody MGC133252 antibody OTTHUMP00000160643 antibody OTTHUMP00000165781 antibody OTTHUMP00000224241 antibody OTTHUMP00000224242 antibody OTTHUMP00000224243 antibody
• Abbreviation: GluR-1, GluA1, GRIA1
• CAS Number: 9000-83-3
• Swiss Prot: P42261 Human, P23818 Mouse, P19490 Rat
• Cellular Locus: Cell membrane, Endoplasmic reticulum membrane, Cell junction, Cell projection.
• Host: Rabbit
• Species Reactivity: Mouse, Rat, Human
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser845 of Human GluR1 aa 831-880 / 906.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, FC
• Positive Control: Mouse brain tissue lysate, rat brain tissue lysate, mouse brain tissue lysate the membrane treated with λpp for 1 hour, rat brain tissue lysate the membrane treated with λpp for 1 hour, N2A.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;FC: 1:10-1:50
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 102 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes