Phospho-MSK1 (S376) Recombinant Rabbit Monoclonal Antibody [SN63-05]

Phospho-MSK1 (S376) Recombinant Rabbit Monoclonal Antibody [SN63-05]

• Description: The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, have been implicated as important signaling intermediates in response to a broad range of ligand-activated receptor tyrosine kinases. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. A related S6 kinase, p70 S6 kinase, functions to phosphorylate the S6 protein on ribosomal 40S subunits. p70 S6 kinase b shares high sequence homology with p70 S6 kinase, except in the carboxy terminus where it contains a proline-rich domain that may be involved in SH3 domain containing protein interactions. MSK1 (also designated RLPK) is related to Rsk and p70 S6 kinase family members and is thought to be structurally similar to Rsk family members, but it may be regulated by distinct mechanisms.
• Product Name Alternative: 90 kDa ribosomal protein S6 kinase 5 antibody EC 2.7.11.1 antibody KS6A5_HUMAN antibody MGC1911 antibody Mitogen and stress activated protein kinase 1 antibody MSPK1 antibody Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody Nuclear mitogen- and stress-activated protein kinase 1 antibody Ribosomal protein S6 kinase 90kD polypeptide 5 antibody Ribosomal protein S6 kinase 90kDa antibody Ribosomal protein S6 kinase 90kDa polypeptide 5 antibody Ribosomal Protein S6 Kinase Alpha 5 antibody Ribosomal protein S6 kinase alpha-5 antibody RLPK antibody RPS6KA5 antibody RSK Like Protein Kinase antibody RSK-like protein kinase antibody RSKL antibody S6K alpha 5 antibody S6K-alpha-5 antibody
• Abbreviation: S6K-alpha-5, RSKL, RPS6KA5
• CAS Number: 9000-83-3
• Swiss Prot: O75582 Human
• Cellular Locus: Nucleus, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Rat
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser376 of Human MSK1 aa 351-400 / 802.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, IP
• Positive Control: HEK-293 cells treated with 200nM PMA for 30 minutes, human colon tissue, rat bladder tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 90 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes