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Cullin 4B Rabbit Polyclonal Antibody

CAT: 0992-ER2001-65Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER2001-65Size:100 µL
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Description
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis.
CAS Number
9007-83-4
Product Name Alternative
CUL 4B antibody CUL-4B antibody CUL4B antibody CUL4B_HUMAN antibody Cullin-4B antibody DKFZp686F1470 antibody KIAA0695 antibody MRXHF2 antibody MRXSC antibody SFM2 antibody
Abbreviation
CUL-4B\Cullin-4B
Swiss Prot
Q13620 Human, A2A432 Mouse
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within human Cullin 4B aa 850-913.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
HUVEC cell lysates, rat cerebellum tissue, human colon tissue, mouse testis tissue, Daudi.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IHC-P: 1:200-1:1,000;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 103/84 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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