Cullin 4B Rabbit Polyclonal Antibody
CAT:
992-ER2001-65
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Cullin 4B Rabbit Polyclonal Antibody
- Description: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8. With CUL4A, contributes to ribosome biogenesis.
- Product Name Alternative: CUL 4B antibody CUL-4B antibody CUL4B antibody CUL4B_HUMAN antibody Cullin-4B antibody DKFZp686F1470 antibody KIAA0695 antibody MRXHF2 antibody MRXSC antibody SFM2 antibody
- Abbreviation: CUL-4B\Cullin-4B
- CAS Number: 9007-83-4
- Swiss Prot: Q13620 Human, A2A432 Mouse
- Cellular Locus: Nucleus.
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Synthetic peptide within human Cullin 4B aa 850-913.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IHC-P, FC
- Positive Control: HUVEC cell lysates, rat cerebellum tissue, human colon tissue, mouse testis tissue, Daudi.
- Concentration: 1 mg/mL
- Dilution: WB: 1:500-1:1,000;IHC-P: 1:200-1:1,000;FC: 1:50-1:100
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 103/84 kDa.
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
- Recombinant Antibody: No