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LSD1 Rabbit Polyclonal Antibody

CAT: 0992-ER1802-12Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1802-12Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Histone methylation regulates chromatin structure and transcription and maintains an epigenetic state of the cell. Histone methylation is dynamically regulated by histone methylases and demethylases. Lysine-specific histone demethylase 1 (LSD1), also designated BHC110, is a flavin-dependent amine oxidase which catalyzes the removal of one or two methyl groups from the methyl-lysine-4 side chain of Histone H3. The LSD1 protein contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. Association with CoREST, a SANT domain-containing corepressor, positively regulates LSD1. CoREST mediates the demethylation ability of LSD1 and protects it from proteasomal degradation in vivo. PHF21A (also designated BCH80), a PHD domain-containing protein, inhibits activity of LSD1/CoREST mediated de-methylation. The LSD1 protein also co-localizes with the androgen receptor in human prostate tumor cells and in unaffected prostate cells, stimulating androgen-receptor-dependent transcription.
CAS Number
9007-83-4
Product Name Alternative
Amine oxidase (flavin containing) domain 2 antibody Amine oxidase, flavin containing, 2 antibody AOF2 antibody BHC110 antibody BRAF35 HDAC complex protein BHC110 antibody BRAF35-HDAC complex protein BHC110 antibody BRAF35/HDAC complex, 110-kD subunit antibody CPRF antibody EC1 antibody FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody Flavin-containing amine oxidase domain-containing protein 2 antibody KDM 1 antibody KDM1 antibody Kdm1a antibody KDM1A_HUMAN antibody KIAA0601 antibody LSD 1 antibody LSD1 antibody Lysine (K) specific demethylase 1 antibody Lysine (K) specific demethylase 1A antibody Lysine demethylase 1A antibody Lysine specific histone demethylase 1 antibody Lysine specific histone demethylase 1A antibody Lysine-specific demethylase 1 antibody Lysine-specific demethylase 1A antibody Lysine-specific histone demethylase 1A antibody
Abbreviation
KDM1A, AOF2, KDM1, KIAA0601, LSD1
Swiss Prot
O60341 Human, Q6ZQ88 Mouse
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within C-terminal human LSD1.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
PC-12 cell lysates, SiHa cell lysates, A431, HepG2, SH-SY-5Y, rat kidney tissue, human colon cancer tissue, human spleen tissue, human kidney tissue, mouse cerebellum tissue, K562.
Concentration
1 mg/mL
Dilution
WB: 1:500-1,000 ;IF-Cell: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 93 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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