AIM2 Rabbit Polyclonal Antibody

CAT: 0992-HA500270Size: 100 µLDry Ice: NoHazardous: No
CAT#:0992-HA500270Size:100 µL
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Description
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. In absence of dsDNA pyrin and HIN-20 domain can interact inducing a closed conformation; an autoinhibitory mechanism is proposed in which binding to dsDNA liberates the pyrin domain for homotypic downstream signaling interactions with PYCARD.
CAS Number
9007-83-4
Product Name Alternative
Absent in melanoma 2 antibody AIM 2 antibody Aim2 antibody AIM2_HUMAN antibody Interferon-inducible protein AIM2 antibody OTTHUMP00000035296 antibody PYHIN4 antibody
Abbreviation
Interferon-inducible protein AIM2 Absent in melanoma 2
Swiss Prot
O14862 Human
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human AIM2 aa 50-150 / 343.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
Hela cell lysates, A431, Hela.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IF-Cell: 1:50 ;FC: 1:500-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 39 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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