Cullin 3 Recombinant Rabbit Monoclonal Antibody [JE37-29]

Cullin 3 Recombinant Rabbit Monoclonal Antibody [JE37-29]

• Description: Cullin 3 is a protein that in humans is encoded by the CUL3 gene. Cullin 3 protein belongs to the family of cullins which in mammals contains eight proteins (Cullin 1, Cullin 2, Cullin 3, Cullin 4A, Cullin 4B, Cullin 5, Cullin 7 and Cullin 9). Cullin proteins are an evolutionarily conserved family of proteins throughout yeast, plants and mammals. Cullin 3 is a component of Cullin-RING E3 ubiquitin ligases complexes (CRLs) which are involved in protein ubiquitylation and represent a part of ubiquitin–proteasome system (UPS). Added ubiquitin moieties to the lysine residue by CRLs then target the protein for the proteasomal degradation. Cullin-RING E3 ubiquitin ligases are involved in many cellular processes responsible for cell cycle regulation, stress response, protein trafficking, signal transduction, DNA replication, transcription, protein quality control, circadian clock and development.
• Product Name Alternative: CUL 3 antibody Cul-3 antibody cul3 antibody CUL3_HUMAN antibody Cullin 3 antibody Cullin-3 antibody Cullin3 antibody KIAA0617 antibody PHA2E antibody
• Abbreviation: CUL3, KIAA0617
• CAS Number: 9000-83-3
• Swiss Prot: Q13618 Human, Q9JLV5 Mouse, B5DF89 Rat
• Cellular Locus: Nucleus, Golgi apparatus, Cell projection, cilium, flagellum, Cytoplasm, cytoskeleton, spindle, cytoskeleton, microtubule organizing center, centrosome, cytoskeleton, spindle pole.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Cullin 3 aa 719-768 / 768.
• Isotype: IgG
• Clone: JE37-29
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: SW480 cell lysate, SW620 cell lysate, HT-29 cell lysate, mouse testis tissue lysate, rat testis tissue lysate, mouse brain tissue lysate, rat brain tissue lysate, human breast carcinoma tissue, human colon carcinoma tissue, human testis tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:200-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 89 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes