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PF-02413873

CAT: 0804-HY-11028-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-11028-01Size:5 mg
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Description
PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. PF-02413873 can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo[1][2].
CAS Number
[936345-35-6]
Product Name Alternative
PF-2413873
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Progesterone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/pf-02413873.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=C(C)C=C(OC2=C(C)N(CS(=O)(C)=O)N=C2C3CC3)C=C1C
Molecular Formula
C18H21N3O3S
Molecular Weight
359.44
Precautions
H302, H315, H319
References & Citations
[1]Howe DC, et, al. The translational efficacy of a nonsteroidal progesterone receptor antagonist, 4-[3-cyclopropyl-1- (mesylmethyl) -5-methyl-1H-pyrazol-4-yl]oxy, -2,6-dimethylbenzonitrile (PF-02413873), on endometrial growth in macaque and human. J Pharmacol Exp Ther. 2011 Nov;339 (2) :642-53.|[2]Bungay PJ, et, al. Preclinical and clinical pharmacokinetics of PF-02413873, a nonsteroidal progesterone receptor antagonist. Drug Metab Dispos. 2011 Aug;39 (8) :1396-405.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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