PF-06679142

CAT: 0804-HY-120270-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120270-01Size:1 mg
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Description
PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC50 of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research[1].
CAS Number
[1467059-66-0]
UNSPSC
12352005
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pf-06679142.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CNC2=CC(F)=C(C3=CC=C([C@]4([H])CCCCO4)C=C3)C(F)=C21)=O
Molecular Formula
C20H17F2NO3
Molecular Weight
357.35
References & Citations
[1]Edmonds DJ, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK) . J Med Chem. 2018 Mar 22;61 (6) :2372-2383.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK α1β1γ1

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