PF-06679142

• Description :

  PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC50 of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research[1].

• UNSPSC :

  12352005

• Target :

  AMPK

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; PI3K/Akt/mTOR

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pf-06679142.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C1=CNC2=CC(F)=C(C3=CC=C([C@]4([H])CCCCO4)C=C3)C(F)=C21)=O

• Molecular Formula :

  C20H17F2NO3

• Molecular Weight :

  357.35

• References & Citations :

  [1]Edmonds DJ, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK) . J Med Chem. 2018 Mar 22;61 (6) :2372-2383.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AMPK α1β1γ1

• CAS Number :

  [1467059-66-0]