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PF-06733804

CAT: 0804-HY-112434Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112434Size:5 mg
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Description
PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].
CAS Number
[1873373-33-1]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Trk-IN-3.html
Solubility
10 mM in DMSO
Smiles
NC1=C(O[C@@H]2C(F)(F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C2)C=C(C(NC)=O)C=N1
Molecular Formula
C20H19F5N4O4
Molecular Weight
474.38
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61 (15) :6779-6800.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkB; TrkC

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