PF-06733804

• Description :

  PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335

• Target :

  Trk Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Trk-IN-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=C(O[C@@H]2C(F)(F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)C2)C=C(C(NC)=O)C=N1

• Molecular Formula :

  C20H19F5N4O4

• Molecular Weight :

  474.38

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61 (15) :6779-6800.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TrkA; TrkB; TrkC

• CAS Number :

  [1873373-33-1]