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PF-592379

CAT: 0804-HY-U00400Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-U00400Size:1 Each
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Description
PF-592379 is a potent dopamine D3 receptor agonist with an EC50 of 21 nM.
CAS Number
710655-15-5
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-Pyridinamine,_5-[_2R,5S_-5-methyl-4-propyl-2-morpholinyl]-.html
Solubility
10 mM in DMSO
Smiles
NC1=NC=C([C@@H]2CN(CCC)[C@@H](C)CO2)C=C1
Molecular Formula
C13H21N3O
Molecular Weight
235.33
References & Citations
[1]Attkins N, et al. Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human. Xenobiotica. 2010 Nov;40 (11) :730-42.|[2]Wager TT, et al. Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects. ACS Chem Neurosci. 2017 Jan 18;8 (1) :165-177.|[3]Collins GT, et al. Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behav Pharmacol. 2012 Jun;23 (3) :280-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D3 Receptor

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