PF-592379

• Description :

  PF-592379 is a potent dopamine D3 receptor agonist with an EC50 of 21 nM.

• CAS Number :

  [710655-15-5]

• UNSPSC :

  12352005

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/2-Pyridinamine,_5-[_2R,5S_-5-methyl-4-propyl-2-morpholinyl]-.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=NC=C([C@@H]2CN(CCC)[C@@H](C)CO2)C=C1

• Molecular Formula :

  C13H21N3O

• Molecular Weight :

  235.33

• References & Citations :

  [1]Attkins N, et al. Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human. Xenobiotica. 2010 Nov;40 (11) :730-42.|[2]Wager TT, et al. Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects. ACS Chem Neurosci. 2017 Jan 18;8 (1) :165-177.|[3]Collins GT, et al. Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behav Pharmacol. 2012 Jun;23 (3) :280-91.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  D3 Receptor