PF-592379

• UNSPSC Description:

  PF-592379 is a potent dopamine D3 receptor agonist with an EC50 of 21 nM.

• Target Antigen:

  Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/2-Pyridinamine,_5-[_2R,5S_-5-methyl-4-propyl-2-morpholinyl]-.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC=C([C@@H]2CN(CCC)[C@@H](C)CO2)C=C1

• Molecular Weight:

  235.33

• References & Citations:

  [1]Attkins N, et al. Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human. Xenobiotica. 2010 Nov;40(11):730-42.|[2]Wager TT, et al. Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects. ACS Chem Neurosci. 2017 Jan 18;8(1):165-177.|[3]Collins GT, et al. Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behav Pharmacol. 2012 Jun;23(3):280-91.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  710655-15-5