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PF-06462894

CAT: 0804-HY-103491Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-103491Size:1 Each
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Description
PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator profiled in both rat and nonhuman primates[1].
CAS Number
1622291-66-0
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-06462894.html
Smiles
O=C1C=C(OCC2=CC=CC=N2)N=C3N1[C@H](CC(C)(C)C)COC3
Molecular Formula
C18H23N3O3
Molecular Weight
329.39
References & Citations
[1]Antonia F. Stepan, et al. Discovery and Characterization of (R) -6-Neopentyl-2- (pyridin-2-ylmethoxy) -6,7-dihydropyrimido[2,1-c][1,4]oxazin-4 (9H) -one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. J. Med. Chem. 2017, 60, 18, 7764–7780
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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