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PF-04577806

CAT: 0804-HY-139467Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-139467Size:1 Each
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Description
PF-04577806 is a potent, selective and ATP competitive PKC inhibitor. PF-04577806 shows potent inhibitory activity towards PKCα, PKCβI, PKCβII, PKCγ, and PKCθ with IC50s of 2.4 nM, 8.1 nM, 6.9 nM, 45.9 nM, and 29.5 nM, respectively. PF-04577806 can reverse retinal vascular leakage in diabetic rats[1].
CAS Number
[1072100-81-2]
UNSPSC
12352005
Target
PKC; SHP2
Type
Reference compound
Related Pathways
Epigenetics; Protein Tyrosine Kinase/RTK; TGF-beta/Smad
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pf-04577806.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=N1)NC2=NNC3=C2CN(C(N4[C@H](CN([C@@H](C4)C)CC5CCOCC5)C)=O)C3(C)C
Molecular Formula
C26H37N7O3
Molecular Weight
495.62
References & Citations
[1]Grant S, et, al. Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model. Eur J Pharmacol. 2010 Feb 10;627 (1-3) :16-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCθ

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