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PF-6422899

CAT: 0804-HY-135727Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135727Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-6422899 is an inhibitor for EGFR, that it selectively binds to EGFR and SOAT1 in nanomolar levels[1].
CAS Number
1621002-23-0
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-6422899.html
Smiles
C=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC#C)=O
Molecular Formula
C20H14ClFN4O2
Molecular Weight
396.80
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]van Bergen W, et al., Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs. ACS Chem Biol. 2024 Aug 16;19 (8) :1705-1718.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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