SB-215505

CAT: 0804-HY-18596-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-18596-01Size:5 mg

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Description

SB-215505 is an orally active and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively[1]. SB-215505 increases wakefulness and motor activity in rats[2].

CAS Number

162100-15-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-215505.html

Purity

98.91

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1CCC2=C1C=C(Cl)C(C)=C2)NC3=C4C=CC=NC4=CC=C3

Molecular Formula

C19H16ClN3O

Molecular Weight

337.80

Precautions

H302, H315, H319, H335

References & Citations

[1]C Reavill, et al. Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126 (3) :572-4.|[2]Sandor Kantor, et al. Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505. J Pharmacol. 2004 Aug;142 (8) :1332-42.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT2 Receptor; α-1 microglobulin

Chemical Information

SB 215505

a neuroleptic with equivalent or higher antagonist affinity for 5-HT2 than for dopamine D2 receptor

CAS Number	162100-15-4
PubChem CID	10449757
IUPAC Name	6-chloro-5-methyl-N-quinolin-5-yl-2,3-dihydroindole-1-carboxamide
Molecular Formula	C19H16ClN3O
Molecular Weight	337.8
XLogP	4
Topological Polar Surface Area	45.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Heavy Atom Count	24
Formal Charge	0
Complexity	474

SMILES

CC1=CC2=C(C=C1Cl)N(CC2)C(=O)NC3=CC=CC4=C3C=CC=N4

InChI

InChI=1S/C19H16ClN3O/c1-12-10-13-7-9-23(18(13)11-15(12)20)19(24)22-17-6-2-5-16-14(17)4-3-8-21-16/h2-6,8,10-11H,7,9H2,1H3,(H,22,24)

InChIKey

HOVMHIRTZYQSKM-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 162100-15-4

CID: 10449757

Formula: C19H16ClN3O

MW: 337.8

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	337.8
XLogP3	4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	337.0981898
Monoisotopic Mass	337.0981898
Topological Polar Surface Area	45.2 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	474
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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