α-Amylase/α-Glucosidase-IN-12

• UNSPSC Description:

  α-Amylase/α-Glucosidase-IN-12 (compound 10k) is a dual inhibitor targeting α-glucosidase and α-amylase with IC50 of 34.52 nM and 24.62 nM, respectively. α-Amylase/α-Glucosidase-IN-12 is an inhibitor designed based on triazolo[4,3-b][1,2,4]triazine and has the potential to be used in diabetes research[1].

• Target Antigen:

  Amylases; Glycosidase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/α-amylase-α-glucosidase-in-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=C(C(F)(F)F)C=C1)CSC2=NN=C3N2N=C(C4=CC=CC=C4)C=N3

• Molecular Weight:

  430.41

• References & Citations:

  [1]Seyfi S, et al. Synthesis, biological activities, and molecular docking studies of triazolo[4,3-b]triazine derivatives as a novel class of α-glucosidase and α-amylase inhibitors. Arch Pharm (Weinheim). 2024 Mar 19:e2300628.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported