α-Amylase/α-Glucosidase-IN-5

α-Amylase/α-Glucosidase-IN-5

• UNSPSC Description: α-Amylase/α-Glucosidase-IN-5 (compound 4l) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC50s of 5.96 μM and 1.62 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity[1].
• Target Antigen: Amylases; Glycosidase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/α-amylase-α-glucosidase-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: BrC1=CC(C(P(OC)(OC)=O)NC2=CC=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)N3)C=C2)=CC=C1
• Molecular Weight: 588.43
• References & Citations: [1]Zareei S, et al. Discovery of novel 4,5-diphenyl-imidazol-α-aminophosphonate hybrids as promising anti-diabetic agents: Design, synthesis, in vitro, and in silico enzymatic studies. Bioorg Chem. 2023 Sep 9;141:106846.. .
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported