α-Amylase/α-Glucosidase-IN-2

• UNSPSC Description:

  α-Amylase/α-Glucosidase-IN-2 (compound 5) is a potent α-amylase and α-glucosidase dual inhibitor with IC50 values of 13.02, 13.09 µM for α-amylase and α-glucosidase, respectively. α-Amylase/α-Glucosidase-IN-2 has the potential for the research of diabetic complications[1].

• Target Antigen:

  Glycosidase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/α-amylase-α-glucosidase-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CC=C(C=C1)/C=N/NC2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N=N2

• Molecular Weight:

  385.85

• References & Citations:

  [1]Shamim S, et al. Synthesis and screening of (E)-3-(2-benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazine analogs as novel dual inhibitors of α-amylase and α-glucosidase. Bioorg Chem. 2020 Aug;101:103979.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2446063-14-3