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WRG-28

CAT: 0804-HY-114169-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114169-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs) . WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice[1][2].
CAS Number
1913291-02-7
UNSPSC
12352005
Target
Discoidin Domain Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/wrg-28.html
Purity
99.76
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(COC2=CC(OC3=CC(C=CC3=N4)=O)=C4C=C2)C=C1)(NCC)=O
Molecular Formula
C21H18N2O5S
Molecular Weight
410.44
References & Citations
[1]Grither WR, et al. Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain. Proc Natl Acad Sci U S A. 2018 Aug 14;115 (33) :E7786-E7794.|[2]Mu N, et al. Blockade of Discoidin Domain Receptor 2 as a Strategy for Reducing Inflammation and Joint Destruction in Rheumatoid Arthritis Via Altered Interleukin-15 and Dkk-1 Signaling in Fibroblast-Like Synoviocytes. Arthritis Rheumatol. 2020 Jun;72 (6) :943-956.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DDR2

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Alternative Products

CatalogName
BA8897-50WRG-28
A18832-10WRG-28 10mg
A18832-100WRG-28 100mg
A18832-50WRG-28 50mg
A18832-25WRG-28 25mg
A18832-5WRG-28 5mg
A18832-1WRG-28 1mg
A18832-10mM-DWRG-28 10mM * 1mL in DMSO
066-79HSM1 (28-69) / EMC10 (28-69) / INM02 (28-69) (Human)
066-81HSM1 (28-69) / EMC10 (28-69) / INM02 (28-69) (Mouse)

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