VK-28

CAT: 0804-HY-W686216-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W686216-01Size:1 mg
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Description
VK-28, a brain-permeable iron chelator, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 μM. VK-28 exhibits significant neuroprotective effects on ICV-6-OHDA. VK-28 can be used for the research of Parkinson’s disease and other neurodegenerative diseases[1].
CAS Number
[312611-92-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vk-28.html
Purity
97.17
Solubility
10 mM in DMSO
Smiles
OCCN1CCN(CC1)CC2=C3C=CC=NC3=C(C=C2)O
Molecular Formula
C16H21N3O2
Molecular Weight
287.36
Precautions
H302, H315, H319
References & Citations
[1]Shachar DB, et al. Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats. Neuropharmacology. 2004 Feb;46 (2) :254-63.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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