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TGX-115

CAT: 0804-HY-124535-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124535-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated PI (3,4) P2 and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus[1][2].
CAS Number
351071-62-0
UNSPSC
12352005
Hazard Statement
H315, H319
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tgx-115.html
Purity
99.25
Solubility
10 mM in DMSO
Smiles
O=C1C=C(N2CCOCC2)NC3=C1C=CC=C3OC4=C(C)C=CC=C4
Molecular Formula
C20H20N2O3
Molecular Weight
336.38
Precautions
H315, H319
References & Citations
[1]Fan QW, et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May;9 (5) :341-9. |[2]Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125 (4) :733-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kβ; PI3Kδ

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