CC-115

• UNSPSC Description:

  CC-115 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.

• Target Antigen:

  DNA-PK; mTOR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CC-115.html

• Solubility:

  DMSO : 20 mg/mL (ultrasonic)

• Smiles:

  O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2

• Molecular Weight:

  336.35

• References & Citations:

  [1]Mortensen DS, et al. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58(14):5599-5608.Front Pharmacol. 2020 Nov 11;11:580407.|Sci Data. 2024 Sep 19.|Front Pharmacol. 2020 Nov 11;11:580407.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Phase 1

• CAS Number:

  1228013-15-7