CC-115

• Description :

  CC-115 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  DNA-PK; mTOR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/CC-115.html

• Purity :

  99.82

• Solubility :

  DMSO : 20 mg/mL (ultrasonic)

• Smiles :

  O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2

• Molecular Formula :

  C16H16N8O

• Molecular Weight :

  336.35

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Mortensen DS, et al. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58 (14) :5599-5608.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  MTOR; mTORC1; mTORC2

• Citation 01 :

  Front Pharmacol. 2020 Nov 11;11:580407.|Sci Data. 2024 Sep 19;11 (1) :1024.|Front Pharmacol. 2020 Nov 11;11:580407.

• CAS Number :

  [1228013-15-7]