CC-115

• Description:

  CC-115 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  DNA-PK; mTOR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CC-115.html

• Purity:

  99.82

• Solubility:

  DMSO : 20 mg/mL (ultrasonic)

• Smiles:

  O=C1CN=C2C (N1CC) =NC (C3=C (C) N=C (C4=NN=CN4) C=C3) =CN2

• Molecular Formula:

  C16H16N8O

• Molecular Weight:

  336.35

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Mortensen DS, et al. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58 (14) :5599-5608.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  MTOR; mTORC1; mTORC2

• Citation 01:

  Front Pharmacol. 2020 Nov 11;11:580407.|Sci Data. 2024 Sep 19;11 (1) :1024.|Front Pharmacol. 2020 Nov 11;11:580407.

• CAS Number:

  1228013-15-7