BMS-066

CAT: 0804-HY-18710-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18710-01Size:1 mg
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Description
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively.
CAS Number
[914946-88-6]
UNSPSC
12352005
Target
IKK; JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/BMS-066.html
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1C=NC2=C1C(C=C(C3=CC=CC(CNC(COC)=O)=N3)N4)=C4N=C2NC
Molecular Formula
C19H21N7O2
Molecular Weight
379.42
References & Citations
[1]Gillooly KM, et al. Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis. J Pharmacol Exp Ther. 2009 Nov;331 (2) :349-60.|[2]Tokarski JS, et al. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. J Biol Chem. 2015 Apr 24;290 (17) :11061-74.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β; Tyk2

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