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IT 066 (hydrochloride)

CAT: 0804-HY-19105ASize: 1 EachDry Ice: NoHazardous: No
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Description
IT 066 hydrochloride is a Histamine H2 receptor antagonist. IT 066 hydrochloride possesses antioxidant activity and can protect rats against acute gastric mucosal injury induced by ischemia-reperfusion. IT 066 hydrochloride can also inhibit secretagogue-induced gastric acid secretion in rats and exert a long-acting anti-lesion effect on experimental gastric and duodenal lesions in rats. IT 066 hydrochloride is applicable for the research of gastrointestinal diseases[1][2].
CAS Number
126463-66-9
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1C(C(N)=C1NC/C=C\COC2=NC=CC(CN3CCCCC3)=C2)=O.Cl
Molecular Formula
C19H25ClN4O3
Molecular Weight
392.88
References & Citations
[1]Naito Y, et al. Effect of a novel histamine H2 receptor antagonist, IT-066, on acute gastric injury induced by ischemia-reperfusion in rats, and its antioxidative properties. Eur J Pharmacol. 1995 Dec 27;294 (1) :47-54.|[2]Isobe Y, et al. Antisecretory and antilesional effect of a new histamine H2-receptor antagonist, IT-066, in rats. J Pharmacol Exp Ther. 1990 Dec;255 (3) :1078-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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