TPP-1

• Description :

  TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM) . TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function[1].

• UNSPSC :

  12352209

• Target :

  PD-1/PD-L1

• Type :

  Peptides

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tpp-1.html

• Purity :

  99.13

• Solubility :

  H2O : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(N1[C@@H](CCC1)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CO)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CS)NC([C@@H](NC([C@H](CS)NC([C@@H](NC([C@@H](NC([C@H](CO)NC([C@H](C)NC([C@@H](NC([C@H](CCC(N)=O)NC(CNC([C@@H](N)CO)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)CC4=CN=CN4)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)CC7=CNC8=CC=CC=C78)=O)=O

• Molecular Formula :

  C107H150N34O32S2

• Molecular Weight :

  2488.67

• References & Citations :

  [1]Chunlin Li, et al. Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 2018 Feb;6 (2) :178-188.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [2426685-25-6]