CPPA-TPP

• Description :

  CPPA-TPP (CPPA-Triphenylphosphonium) is a compound conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP) . CPPA-TPP can be used in the synthesis of nanoparticles that release Camptothecin (HY-16560) in a reactive oxygen species dependent manner, leading to cancer cell death[1].

• Product Name Alternative :

  CPPA-Triphenylphosphonium

• UNSPSC :

  12352005

• Target :

  Drug Intermediate

• Related Pathways :

  Others

• Field of Research :

  Cancer

• Smiles :

  O=C(OCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)CCC(C)(SC(C4=CC=CC=C4)=S)C#N.[Br-]

• Molecular Formula :

  C33H31BrNO2PS2

• Molecular Weight :

  648.61

• References & Citations :

  [1]Zhang W, et al. Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy. Nat Commun. 2019 Apr 12;10 (1) :1704. doi: 10.1038/s41467-019-09566-3. Erratum in: Nat Commun. 2019 Jun 10;10 (1) :2597.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported